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Please be noted that contents are in English/Japanese, translated on a request basis from authors/members.



Cutting-edge Peptide Synthesis Technology “Molecular Hiving?”

Molecular Hiving ™ technology is a kind of liquid phase peptide synthesis using hydrophobic benzyl alcohol or benzylamine etc(innovative TAG -assisted liquid phase peptide synthesis). This technology can produce peptides in high quality with a short lead time and low cost.
As for GMP manufacturing, it is possible to be carried out at a partner company.
  • Target market
    Japan, USA, Other countries
  • Business category
    Pharmaceutical, Biopharmaceutical, Others
  • Business function
    Clinical development > CRO selection, Regulatory > Regulatory affairs, Engineering, production, GMP > Engineering, Engineering, production, GMP > GMP, QMS, Engineering, production, GMP > CDMO selection, Business consulting > Licensing
  • Keyword
  • Author
    "Takashi Yamasaki" of "Jitsubo CO., LTD. / JITSUBO株式会社"
  • Availability


Advantage of Molecular Hiving ™
A : No need to change your conventional facilities. 
B : Significant reduction of excessive raw materials.
C : Easy to produce at large scale under GMP guideline.
D : Easy to handle to check reaction process of HPLC step by step.
E : Less consumption of solvent compared to SPPS and environment friendly.

Molecular Hiving™ Technology
Molecular HivingTM is a technology to manufacture peptides with innovative TAG-assisted liquid phase peptide synthesis (LPPS) and provides us with a high-quality and low-cost peptide APIs with short lead time. Molecular HivingTM can clearly reduce the raw material cost and the impurities in the crude. Molecular HivingTM can be applied to the manufacture of variety peptides and can contribute the high quality of APIs with short lead time.

-Combine the advantages of the Solid Phase Peptide Synthesis (SPPS) and the traditional Liquid Phase Peptide Synthesis (LPPS).

-Reduce significantly the raw material consumption during the sequential elongation.

-Reduce the load in the final purification process by high purity crude.

-Control the quality of every intermediates by well-established in-process control using the UHPLC analytical techniques.

-Short lead time of the sequential elongation steps using the one-pot synthetic strategy

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